| 陈甜甜,王聪,刘婉嫕,栾云浩,李宇航,刘鹏涛,刘忠.pH响应性纤维素纳米纤丝/海藻酸钠基水凝胶的制备及其释药性研究[J].中国造纸学报,2022,37(1):16-21 |
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| pH响应性纤维素纳米纤丝/海藻酸钠基水凝胶的制备及其释药性研究 |
| Study on Preparation and Drug Release of pH-responsive Cellulose Nanofibril/ Sodium Alginate-based Hydrogel |
| 投稿时间：2021-01-22 |
| DOI：10.11981/j.issn.1000-6842.2022.01.16 |
| 中文关键词: 纤维素纳米纤丝 阿司匹林 pH响应性水凝胶 药物控释 |
| Key Words:cellulose nanofibril aspirin pH-responsive hydrogel drug controlled release |
| 基金项目:国家重点研发计划重点专项资助项目（2017YFB0307902）。 |
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| 中文摘要: |
| 将纤维素纳米纤丝（CNF）和海藻酸钠（SA）共混，然后在CaCl2的交联作用下，制得具有pH响应性的CNF/SA水凝胶，并通过物理包裹的方式将阿司匹林（ASP）、CNF和SA三者混合均匀后，在CaCl2的交联作用下制得ASP/CNF/SA载药水凝胶，研究ASP在不同pH值环境中的缓释行为。结果表明，ASP/CNF/SA载药水凝胶的载药量为194 mg/g，包封率达49.9%，且药物分子和水凝胶都保持了很好的热稳定性。ASP/CNF/SA载药水凝胶的药物释放具有pH响应性，药物分子的释放速率随着环境pH值的升高而加快。在pH值为1.5~11.0的缓释条件下，药物的释放行为均为溶蚀作用。 |
| Abstract: |
| A pH-responsive cellulose nanofibril （CNF）/sodium alginate （SA） hydrogel was prepared by blending CNF with SA using CaCl2 as cross-linking agent. The aspirin （ASP）/CNF/SA drug-loaded hydrogel was further prepared through physical encapsulation by uniformly mixing ASP， CNF， and SA with subsequent cross-linking action of CaCl2. The controlled-release behavior of ASP was studied in different pH value environment. The results showed that the drug loading and encapsulation efficiency of ASP/CNF/SA drug-loaded hydrogel was 194 mg/g and 49.9%， respectively， and both drug molecules and hydrogels exhibited good thermal stability. It was further demonstrated that the drug release of ASP/CNF/SA drug-loaded hydrogel was pH-responsive， showing accelerated releasing rate with increase in environmental pH value. The drug release behavior presented as dissolution at pH value of 1.5~11.0. |
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