| 杨兰焰,石柳,陈胜,汪兰,吴文锦,陈朗,熊光权,彭勇波,郭晓嘉.用于伤口愈合的细菌纤维素基复合材料的研究进展[J].中国造纸学报,2025,40(3):55-65 |
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| 用于伤口愈合的细菌纤维素基复合材料的研究进展 |
| Research Progress on Bacterial Cellulose-based Composite Materials for Wound Healing |
| 投稿时间：2024-12-12 修订日期：2025-01-07 |
| DOI：10.11981/j.issn.1000-6842.2025.03.55 |
| 中文关键词: 细菌纤维素 伤口敷料 功能化改性 伤口愈合 |
| Key Words:bacterial cellulose wound healing functional modification wound healing |
| 基金项目:中国博士后科学基金（2024M750851）；湖北省杰出青年基金（2022CFA095）。 |
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| 中文摘要: |
| 细菌纤维素（bacterial cellulose，BC）是一种由微生物代谢合成的胞外多糖，因其优异的生物相容性及可调控性，已在生物医学领域得到广泛应用。然而，天然BC并不具备自愈合、抗菌、抗炎或止血功能，需通过物理、化学和生物策略对其进行功能化改性。本文介绍了BC的生物合成原理、制备方法，以及其生物相容性、可生物降解性、高机械性能、高纳米孔隙率等基本功能特性，综述了具备止血、抗菌、抗炎等生物医用功能的BC基复合材料的研究进展；此外，还介绍了BC基复合材料在促凝血材料和伤口敷料中的多样化应用形式，如水凝胶敷料、伤口修复贴片和海绵敷料等；最后，对BC基复合材料在伤口修复领域的发展前景进行展望。 |
| Abstract: |
| Bacterial cellulose （BC）， an extracellular polysaccharide synthesized through microbial metabolism， has been widely utilized in biomedical applications due to its exceptional biocompatibility and tunability. However， natural BC lacks intrinsic self-healing， antibacterial， anti-inflammatory， or hemostatic properties， necessitating functional modifications via physical， chemical， and biological strategies. This article elucidated the biosynthetic principles and preparation methods of BC， along with its fundamental functional characteristics such as biocompatibility， biodegradability， high mechanical strength， and high nano-porosity. Furthermore， it reviewed recent advances in BC-based composite materials endowed with biomedical functionalities， including hemostasis， antibacterial activity， and anti-inflammatory effects. Additionally， diverse application forms of BC-based composites in hemostatic materials and wound dressings， such as hydrogel dressings， wound repair patches， and sponge dressings， were discussed. Finally， the prospects for BC-based composite materials in the field of wound healing were outlined. |
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