| 杨金帆,刘慧敏,史开宏.生物质基控释型水凝胶用于创面修复的研究进展[J].中国造纸学报,2025,40(3):75-84 |
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| 生物质基控释型水凝胶用于创面修复的研究进展 |
| Research Progress on the Application of Biomass-based Controlled-release Hydrogels in Wound Healing |
| 投稿时间：2025-05-14 修订日期：2025-05-16 |
| DOI：10.11981/j.issn.1000-6842.2025.03.75 |
| 中文关键词: 水凝胶 控释型 创面愈合 创面微环境 |
| Key Words:hydrogels controlled-release wound healing trauma microenvironment |
| 基金项目:陕西省科技厅重点研发计划（2024SF-YBXM-441）；教育部春晖计划（HZKY20220518）。 |
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| 中文摘要: |
| 生物质基控释型水凝胶是一种通过对外界刺激做出动态响应，以实现药物精准可控且持续释放的水凝胶材料；因其良好的生物相容性、亲水性及类细胞外基质的独特性能，在创面修复领域展现出显著优势。本文基于不同类型皮肤创面的治疗难点与功能需求，系统总结了生物质基控释型水凝胶用于创面修复的常见响应策略（pH响应、温度响应、光电响应及生物响应）及其应用研究进展，进一步分析了薄膜、喷雾、局部贴片、微针及可注射水凝胶等不同给药方式的优缺点和适用场景，并针对生物质基控释型水凝胶在控释精度、响应速度和适应性等方面的技术问题，对其多模式响应、协同修复和智能监测等发展方向进行展望。 |
| Abstract: |
| The biomass-based controlled-release hydrogels can achieve precise control and continuous drug release by dynamically responding to different external stimuli. It shows significant advantages for wound repair due to its excellent biocompatibility， hydrophilicity， and unique structure similar to extracellular matrix. Based on the treating difficulties and demands of different skin wounds， the paper systematically summarized the common response strategies （e.g.， pH， temperature， photoelectric， biological response） and advanced research progress of controlled-release hydrogels. Moreover， it further analyzed the advantages， disadvantages， and applicable scenarios of different drug-delivery forms （e.g.， films， sprays， patches， microneedles， injectable hydrogels）. Regarding to the technical challenges of controlled-release hydrogels such as the release accuracy， response speed， and adaptability， future research should focus on developing the multi-modal response， collaborative repair and intelligent monitoring and other development directions. |
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