| 唐嵩,胡敬芳,王林哲,魏文松,宋钰,李延生,高国伟.纸基微流控芯片的制备工艺及其在抗生素检测中的应用研究进展[J].中国造纸学报,2025,40(3):94-105 |
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| 纸基微流控芯片的制备工艺及其在抗生素检测中的应用研究进展 |
| Research Progress on the Preparation Process of Paper-based Microfluidic Chips and Their Application in Antibiotic Detection |
| 投稿时间：2024-09-12 修订日期：2024-10-09 |
| DOI：10.11981/j.issn.1000-6842.2025.03.94 |
| 中文关键词: 纸基微流控芯片 抗生素污染 快速检测 |
| Key Words:paper-based microfluidic sensing chips antibiotic contamination rapid detection |
| 基金项目:国家自然科学基金青年项目（61601037，32201952）；国家重点研发计划（2022YFD2100205-01）；农业农村部农产品质量安全收贮运管控重点实验室开放课题（S2024KFKT-18）。 |
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| 中文摘要: |
| 纸基微流控芯片（μPADs）因其制作成本低、环境友好、便于携带等优势，为抗生素快速检测提供了新的研究平台。本文对μPADs基材的制备方法和工艺进行总结，基于不同检测原理，总结了电化学传感、比色传感、荧光传感、侧流免疫层析传感等μPADs的技术特点和结构性能，重点综述了μPADs在环境监测、食品检验及医学诊断领域中抗生素检测的应用研究进展，并分析了μPADs面临的挑战及未来发展方向。 |
| Abstract: |
| Paper-based microfluidic chips （μPADs） have emerged as a novel research platform for rapid antibiotic detection due to their low manufacturing cost， environmental friendliness， and portability. The paper summarized the preparation methods and processes of the μPADs substrate， and based on different detection principles， discussed the technical characteristics and structural performance of μPADs， such as electrochemical sensing， colorimetric sensing， fluorescence sensing， and lateral flow immunoassay sensing. It focused on reviewing the application research progress of μPADs in environmental monitoring， food inspection and medical diagnosis for antibiotic detection， and analyzed the challenges faced by μPADs and their future development directions. |
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