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| Preparation of Cellulose Nanocrystal/Quercetin Nanocomposite and Its Anti-oxidation and Anti-cancer Activities |
| Received:August 18, 2019 |
| DOI：10.11981/j.issn.1000-6842.2020.01.07 |
| Key Words:cellulose nanocrystals (CNC);quercetin;nanocomposite;dissolution rate;anti-oxidation;anti-cancer |
| Author Name | Affiliation | Postcode | | LIU Qingjian* | School of Chemistry and Food Engineering, Changsha University of Science and Technology,Changsha, Hu‘nan Province, 410114 | 410114 | | WANG Yulong | School of Chemistry and Food Engineering, Changsha University of Science and Technology,Changsha, Hu‘nan Province, 410114 | 410114 | | HAN Junyuan | School of Chemistry and Food Engineering, Changsha University of Science and Technology,Changsha, Hu‘nan Province, 410114 | 410114 | | LIU Yanxin | School of Chemistry and Food Engineering, Changsha University of Science and Technology,Changsha, Hu‘nan Province, 410114
School of Materials and Engineering, Central South University of Forestry and Technology,Changsha, Hu’nan Province, 410004 | 410004 |
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| Abstract: |
| Cellulose nanocrystal (CNC) was used as carriers and quercetin as model drug to prepare CNC/quercetin nanocomposites via anti-solvent recrystallization process. The CNC/quercetin nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray diffractometry (XRD),the dissolution rate, anti-oxidation and anti-cancer activities of the resultant nanocomposite were investigated. The results showed that quercetin was fully nanolized and well dispersed in CNC/quercetin nanocomposite, and changed from crystalline state to amorphous state. The dissolution rate of quercetin was significantly enhanced due to the formation of the CNC/quercetin nanocomposite,increased to 92.6% at 120 min, compared with the dissolution rate of original quercetin of 4.7%. Furthermore, in vitro anti-oxidation and anti-cancer activitiy studied results showed that hydroxyl radical and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals scavenging efficiency, as well as anti-cancer effect against HepG2 cells of guercetin were remarkably enhanced, based on the formation of the CNC/quercetin nanocomposites. |
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