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| Quantitative Correlation between Microcrystalline Cellulose Quality Index and Its Tablet Application Performance |
| Received:April 02, 2020 |
| DOI：10.11981/j.issn.1000-6842.2021.01.13 |
| Key Words:microcrystalline cellulose;quality index;application performance;correlation |
| Fund Project:陕西省重点研发计划项目（2017ZDXM-SF-090）；国家重点研发计划项目（2017YFB0307901）。 |
| Author Name | Affiliation | E-mail | | 李金宝* | 陕西科技大学轻工科学与工程学院，轻化工程国家级实验教学示范中心， 陕西省造纸技术及特种纸品开发重点实验室，陕西西安，710021 | lijinbao@sust.edu.cn | | 赵欣 | 陕西科技大学轻工科学与工程学院，轻化工程国家级实验教学示范中心， 陕西省造纸技术及特种纸品开发重点实验室，陕西西安，710021 | | | 修慧娟 | 陕西科技大学轻工科学与工程学院，轻化工程国家级实验教学示范中心， 陕西省造纸技术及特种纸品开发重点实验室，陕西西安，710021 | | | 马飞燕 | 陕西科技大学轻工科学与工程学院，轻化工程国家级实验教学示范中心， 陕西省造纸技术及特种纸品开发重点实验室，陕西西安，710021 | | | 李静宇 | 陕西科技大学轻工科学与工程学院，轻化工程国家级实验教学示范中心， 陕西省造纸技术及特种纸品开发重点实验室，陕西西安，710021 | | | 谢竺航 | 陕西科技大学轻工科学与工程学院，轻化工程国家级实验教学示范中心， 陕西省造纸技术及特种纸品开发重点实验室，陕西西安，710021 | |
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| Abstract: |
| The quality index of microcrystalline cellulose （MCC） has a great impact on its application performance. It is of great importance for pharmaceutical companies to study the correlation between quality index and application performance of MCC in its selection and quality control. In this study， different types of MCC were selected for sieving and the sieved MCCs were made into tablets under the same drug manufacturing conditions. The quantitative correlation between particle size and crystallinity of MCC and its application properties such as tablet hardness， disintegration， and dissolution was established by means of multiple stepwise regression analysis. The results showed that the tablet hardness and crystallinity of MCC showed a linear relationship， i.e.， the greater the crystallinity of MCC， the greater the tablet hardness. With decreasing particle size of MCC， the tablet disintegration gradually increased while the dissolution decreased. |
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