|
二维码（扫一下试试看！） |
| Preparation of pH-responsive Polymeric Micelles based on Sodium Alginate and Its Drug Release Property |
| Received:May 20, 2020 |
| DOI：10.11981/j.issn.1000-6842.2021.02.18 |
| Key Words:sodium alginate;polymeric micelles;pH-responsiveness;biomass material;drug release |
| Fund Project:湖南省自然科学基金项目（2015JJ2008）。 |
| Author Name | Affiliation | Postcode | | HAN Junyuan* | School of Chemistry and Food Engineering， Changsha University of Science and Technology， Changsha， Hu'nan Province， 410114 | 410114 | | WANG Yulong | School of Chemistry and Food Engineering， Changsha University of Science and Technology， Changsha， Hu'nan Province， 410114 | 410114 | | LIU Qingjian | School of Chemistry and Food Engineering， Changsha University of Science and Technology， Changsha， Hu'nan Province， 410114 | 410114 | | LIU Yanxin | School of Chemistry and Food Engineering， Changsha University of Science and Technology， Changsha， Hu'nan Province， 410114 | 410114 |
|
| Hits: 2652 |
| Download times: 1840 |
| Abstract: |
| In this study sodium alginate （SA） was modified with 1-ethyl-3-（3-dimethylaminopropyl） carbodiimide hydrochloride （EDC） and N-hydroxysuccinimide （NHS）， then the sodium alginate-based pH-responsive polymer micelles were prepared. The Fourier transform infrared spectroscopy （FT-IR）， critical micelle concentration （CMC）， particle size， and Zeta potential were analyzed for SA before and after modified by EDC/NHS. The genistein was then encapsulated in polymeric micelles based on anti-solvent recrystallization method， and the drug loading efficiency， drug loading capacity， and pH responsiveness of the polymer micelles were studied. The results showed that EDC/NHS-modified SA could form polymer micelles in water， and its CMC was 0.041 mg/mL. The loading efficiency and drug loading capacity of polymeric micelles were 74.4% and 8.6%， respectively when the mass ratio of polymeric micelles to genistein was 10∶1. The in vitro release study showed that the polymeric micelles loaded with drug were pH-responsive and relatively stable under acidic conditions （pH value=2.0）， and would release drugs under neutral conditions （pH value =7.4）， enabling it to be used as a carrier for oral drugs absorbing by intestinal tract， so as to achieve controlled release and sustained release of drugs. |
| View Full Text View/Add Comment Download reader HTML |
