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| Study on Preparation and Drug Release of pH-responsive Cellulose Nanofibril/ Sodium Alginate-based Hydrogel |
| Received:January 22, 2021 |
| DOI：10.11981/j.issn.1000-6842.2022.01.16 |
| Key Words:cellulose nanofibril;aspirin;pH-responsive hydrogel;drug controlled release |
| Fund Project:国家重点研发计划重点专项资助项目（2017YFB0307902）。 |
| Author Name | Affiliation | Postcode | | CHEN Tiantian* | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 | | WANG Cong | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 | | LIU Wanyi | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 | | LUAN Yunhao | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 | | LI Yuhang | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 | | LIU Pengtao | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 | | LIU Zhong | Tianjin Key Laboratory of Pulp and Paper， Tianjin University of Science and Technology， Tianjin， 300457 | 300457 |
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| Abstract: |
| A pH-responsive cellulose nanofibril （CNF）/sodium alginate （SA） hydrogel was prepared by blending CNF with SA using CaCl2 as cross-linking agent. The aspirin （ASP）/CNF/SA drug-loaded hydrogel was further prepared through physical encapsulation by uniformly mixing ASP， CNF， and SA with subsequent cross-linking action of CaCl2. The controlled-release behavior of ASP was studied in different pH value environment. The results showed that the drug loading and encapsulation efficiency of ASP/CNF/SA drug-loaded hydrogel was 194 mg/g and 49.9%， respectively， and both drug molecules and hydrogels exhibited good thermal stability. It was further demonstrated that the drug release of ASP/CNF/SA drug-loaded hydrogel was pH-responsive， showing accelerated releasing rate with increase in environmental pH value. The drug release behavior presented as dissolution at pH value of 1.5~11.0. |
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