本文二维码信息
二维码(扫一下试试看!)
Cellulose Nanocrystal Reinforced Chitosan-Gelatin-Hydroxyapatite Scaffold for Bone Defect Repair
Received:June 02, 2023  
DOI:10.11981/j.issn.1000-6842.2023.03.39
Key Words:cellulose nanocrystal;bone defect repair scaffold;chitosan;gelatin;hydroxyapatite
Fund Project:国家自然科学基金(22208200);中国博士后科学基金(2020M683409)。
Author NameAffiliationE-mail
NIE Jingyi* College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021 niejingyi@sust.edu.cn 
LIAO Jianfei College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
LIU Xinming College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
LIANG Jiantao College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
ZHANG Le College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
JIAO Tingting College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
SUN Binrong College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
ZHANG Meiyun College of Bioresources Chemical and Materials Engineering, China National Light Industry Key Lab of Paper Based Functional Materials, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi Province, 710021  
Hits: 1649
Download times: 975
Abstract:
      Nanocellulose has excellent characteristics such as high modulus, high strength, and biocompatibility, demonstrating potential applications in the biomedical field. This article aims to use cellulose nanocrystal (CNC) to address issues in the application of bone defect repair scaffolds, such as insufficient strength of natural polymer scaffolds and decreased mechanical strength during the degradation process. Firstly, the chitosan-gelatin-hydroxyapatite composite material simulating the Haversian system in natural bone was formed by self-organization. Then the strengthening effect of CNC on chitosan gel was studied. With CS-CNC composite gel as the structural framework, and chitosan-gelatin-hydroxyapatite composite as the biomimetic part, a combination hydrogel could be formed by interfacial fusion. Finally, the degradation of CS-CNC composite gel was studied in vitro. With the biomimetic structure design and the enhancement of natural polymer scaffold, this work aimed to explore the role of CNC in improving the performance of scaffolds, and explore the potential of nanocellulose in the application in biomedical field.
View Full Text  View/Add Comment  Download reader  HTML

share