水凝胶封装细胞研究进展

贺斌; 成琳; 方一帆; 王科尧; 郑旭磊; 朱兴

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Recent Developments of Hydrogel-encapsulated Cells

Received:June 22, 2023

DOI：10.11981/j.issn.1000-6842.2023.03.57

Key Words:cell shell;hydrogel;cell surface engineering;cytoprotection

Fund Project:国家自然科学基金（52003146，52103008）；陕西省重点研发计划国际科技合作项目（2023-GHZD-14）；陕西省科协青年人才托举计划（20210407）；陕西省自然科学基础研究（2021JQ-541）。

Author Name	Affiliation	E-mail
HE Bin^*	College of Bioresources Chemical & Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 National Demonstration Center for Experimental Light Chemistry Engineering Education， Xi’an， Shaanxi Province， 710021	prof.hebin@sust.edu.cn
CHENG Lin	College of Bioresources Chemical & Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 National Demonstration Center for Experimental Light Chemistry Engineering Education， Xi’an， Shaanxi Province， 710021
FANG Yifan	College of Bioresources Chemical & Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 National Demonstration Center for Experimental Light Chemistry Engineering Education， Xi’an， Shaanxi Province， 710021
WANG Keyao	College of Bioresources Chemical & Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 National Demonstration Center for Experimental Light Chemistry Engineering Education， Xi’an， Shaanxi Province， 710021
ZHENG Xulei	College of Bioresources Chemical & Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 National Demonstration Center for Experimental Light Chemistry Engineering Education， Xi’an， Shaanxi Province， 710021
ZHU Xing	College of Bioresources Chemical & Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 National Demonstration Center for Experimental Light Chemistry Engineering Education， Xi’an， Shaanxi Province， 710021

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Abstract:

Recently， living cells have been widely used in tissue engineering， cell therapy and other fields. To ensure the activity and functional integrity of living cells during the application， a protective shell， was constructed on the cell surface， named cell encapsulation. Cell encapsulation avoids direct contact with immune cells， antibodies， enzymes and other substances， and ensures free exchange of small materials such as oxygen， nutrients and metabolites. Hydrogels have received much attention because of their similarity to the cell matrix and their ability to form 3D structures that mimic the cellular micro-environment. Herein， cell encapsulation is briefly introduced at first， and then the applications of lignocellulose-based hydrogels in cell encapsulation are emphatically introduced in the multi cells encapsulation； In single cell encapsulated， using layer-by-layer self-assembly， Grafting to and Grafting from methods to expound the effects of hydrogel shell on cell activity and function. Finally， the future development directions and prospects of hydrogel-encapsulated cells are discussed， hoping to provide reference values for the applications of living cells in medicine and food fields.

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