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Research Progress of Nanocellulose-based Hydrogels for Biomedical Applications

Received:August 22, 2022

DOI：10.11981/j.issn.1000-6842.2023.04.116

Key Words:nanocellulose;hydrogels;preparation;biomedical applications

Fund Project:“十四五”国家重点研发计划项目（2021YFD2100505）；山东省泰山学者特聘专家项目（TS20190956）。

Author Name	Affiliation	Postcode
LI Zijiang^*	Shandong Institute of Commerce and Technology， Ji’nan， Shandong Province， 250103 National Engineering Research Center for Agricultural Products Logistics， Ji’nan， Shandong Province， 250103 Tianjin Key Lab of Pulp & Paper， School of Light Industry Science and Engineering， Tianjin University of Science & Technology， Tianjin， 300457	300457
ZHANG Jie	Shandong Institute of Commerce and Technology， Ji’nan， Shandong Province， 250103 National Engineering Research Center for Agricultural Products Logistics， Ji’nan， Shandong Province， 250103	250103
GUO Fengjun	Shandong Institute of Commerce and Technology， Ji’nan， Shandong Province， 250103 National Engineering Research Center for Agricultural Products Logistics， Ji’nan， Shandong Province， 250103	250103
WANG Ying	Shandong Institute of Commerce and Technology， Ji’nan， Shandong Province， 250103 National Engineering Research Center for Agricultural Products Logistics， Ji’nan， Shandong Province， 250103	250103
WANG Yaxuan	Tianjin Key Lab of Pulp & Paper， School of Light Industry Science and Engineering， Tianjin University of Science & Technology， Tianjin， 300457	300457
LIU Huayu	Tianjin Key Lab of Pulp & Paper， School of Light Industry Science and Engineering， Tianjin University of Science & Technology， Tianjin， 300457	300457
ZHANG Changfeng	Shandong Institute of Commerce and Technology， Ji’nan， Shandong Province， 250103 National Engineering Research Center for Agricultural Products Logistics， Ji’nan， Shandong Province， 250103	250103
SI Chuanling	Tianjin Key Lab of Pulp & Paper， School of Light Industry Science and Engineering， Tianjin University of Science & Technology， Tianjin， 300457	300457

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Abstract:

Nanocellulose has been widely used in biomedical and other fields because of its high specific surface area （150~250 m²/g）， large aspect ratio， low density （1.6 g/cm³） and excellent mechanical properties （elastic modulus ~150 GPa， high tensile strength ~7.5 GPa）. This paper mainly summarized the research progress of nanocellulose-based hydrogels in recent years. Firstly， the preparation methods of nanocellulose were introduced， including mechanical， acid hydrolysis， TEMPO oxidation and biological methods. Secondly， the common cross-linking methods of nanocellulose-based hydrogels， including physical crosslinking and chemical crosslinking， were listed. Finally， the applications of nanocellulose-based hydrogels in biomedical fields， including wound dressings， tissue engineering and drug delivery， were introduced. In addition， the development direction of nanocellulose-based hydrogels in biomedical field was prospected.

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