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Research Progress on Bacterial Cellulose-based Composite Materials for Wound Healing
Received:December 12, 2024  Revised:January 07, 2025
DOI：10.11981/j.issn.1000-6842.2025.03.55
Key Words:bacterial cellulose;wound healing;functional modification;wound healing
Fund Project:中国博士后科学基金（2024M750851）；湖北省杰出青年基金（2022CFA095）。
Author NameAffiliationPostcode
YANG Lanyan* School of College of Life Sciences， South-Central Minzu University， Wuhan， Hubei Province， 430074
Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 		430064
SHI Liu Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
CHEN Seng Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
WANG Lan Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
WU Wenjin Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
CHEN Lang Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
XIONG Guangquan Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
PENG Yongbo* School of College of Life Sciences， South-Central Minzu University， Wuhan， Hubei Province， 430074 430074
GUO Xiaojia* Agro-Product Processing Research Sub-Center of Hubei Innovation Center of Agriculture Science and Technology， Key Lab of Cold Chain Logistics Technology for Agro-Product， Ministry of Agriculture and Rural Affairs， Institute of Agro-Product Processing and Nuclear Agricultural Technology， Hubei Academy of Agricultural Sciences， Wuhan， Hubei Province， 430064 430064
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Abstract:
      Bacterial cellulose （BC）， an extracellular polysaccharide synthesized through microbial metabolism， has been widely utilized in biomedical applications due to its exceptional biocompatibility and tunability. However， natural BC lacks intrinsic self-healing， antibacterial， anti-inflammatory， or hemostatic properties， necessitating functional modifications via physical， chemical， and biological strategies. This article elucidated the biosynthetic principles and preparation methods of BC， along with its fundamental functional characteristics such as biocompatibility， biodegradability， high mechanical strength， and high nano-porosity. Furthermore， it reviewed recent advances in BC-based composite materials endowed with biomedical functionalities， including hemostasis， antibacterial activity， and anti-inflammatory effects. Additionally， diverse application forms of BC-based composites in hemostatic materials and wound dressings， such as hydrogel dressings， wound repair patches， and sponge dressings， were discussed. Finally， the prospects for BC-based composite materials in the field of wound healing were outlined.
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