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| Research Progress on the Application of Biomass-based Controlled-release Hydrogels in Wound Healing |
| Received:May 14, 2025 Revised:May 16, 2025 |
| DOI：10.11981/j.issn.1000-6842.2025.03.75 |
| Key Words:hydrogels;controlled-release;wound healing;trauma microenvironment |
| Fund Project:陕西省科技厅重点研发计划（2024SF-YBXM-441）；教育部春晖计划（HZKY20220518）。 |
| Author Name | Affiliation | Postcode | | YANG Jinfan* | College of Bioresources Chemical and Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 | 710021 | | LIU Huimin | College of Bioresources Chemical and Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 | 710021 | | SHI Kaihong | College of Bioresources Chemical and Materials Engineering， Shaanxi University of Science & Technology， Xi’an， Shaanxi Province， 710021 | 710021 |
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| Abstract: |
| The biomass-based controlled-release hydrogels can achieve precise control and continuous drug release by dynamically responding to different external stimuli. It shows significant advantages for wound repair due to its excellent biocompatibility， hydrophilicity， and unique structure similar to extracellular matrix. Based on the treating difficulties and demands of different skin wounds， the paper systematically summarized the common response strategies （e.g.， pH， temperature， photoelectric， biological response） and advanced research progress of controlled-release hydrogels. Moreover， it further analyzed the advantages， disadvantages， and applicable scenarios of different drug-delivery forms （e.g.， films， sprays， patches， microneedles， injectable hydrogels）. Regarding to the technical challenges of controlled-release hydrogels such as the release accuracy， response speed， and adaptability， future research should focus on developing the multi-modal response， collaborative repair and intelligent monitoring and other development directions. |
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