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| Research Progress on the Preparation Process of Paper-based Microfluidic Chips and Their Application in Antibiotic Detection |
| Received:September 12, 2024 Revised:October 09, 2024 |
| DOI：10.11981/j.issn.1000-6842.2025.03.94 |
| Key Words:paper-based microfluidic sensing chips;antibiotic contamination;rapid detection |
| Fund Project:国家自然科学基金青年项目（61601037，32201952）；国家重点研发计划（2022YFD2100205-01）；农业农村部农产品质量安全收贮运管控重点实验室开放课题（S2024KFKT-18）。 |
| Author Name | Affiliation | Postcode | | TANG Song | Key Lab of Sensors， Beijing University of Information Science and Technology， Beijing， 100101 | 100101 | | HU Jingfang* | Key Lab of Sensors， Beijing University of Information Science and Technology， Beijing， 100101
Key Lab of Modern Measurement and Control Technology， Ministry of Education， Beijing University of Information Science and Technology， Beijing， 100192 | 100192 | | WANG Linzhe | Key Lab of Sensors， Beijing University of Information Science and Technology， Beijing， 100101
Institute of Agricultural Products Processing， Chinese Academy of Agricultural Sciences， Beijing， 100193 | 100193 | | WEI Wensong | Institute of Agricultural Products Processing， Chinese Academy of Agricultural Sciences， Beijing， 100193 | 100193 | | SONG Yu | Key Lab of Sensors， Beijing University of Information Science and Technology， Beijing， 100101
Key Lab of Modern Measurement and Control Technology， Ministry of Education， Beijing University of Information Science and Technology， Beijing， 100192 | 100192 | | LI Yansheng | Key Lab of Sensors， Beijing University of Information Science and Technology， Beijing， 100101
Key Lab of Modern Measurement and Control Technology， Ministry of Education， Beijing University of Information Science and Technology， Beijing， 100192 | 100192 | | GAO Guowei | Key Lab of Sensors， Beijing University of Information Science and Technology， Beijing， 100101
Key Lab of Modern Measurement and Control Technology， Ministry of Education， Beijing University of Information Science and Technology， Beijing， 100192 | 100192 |
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| Abstract: |
| Paper-based microfluidic chips （μPADs） have emerged as a novel research platform for rapid antibiotic detection due to their low manufacturing cost， environmental friendliness， and portability. The paper summarized the preparation methods and processes of the μPADs substrate， and based on different detection principles， discussed the technical characteristics and structural performance of μPADs， such as electrochemical sensing， colorimetric sensing， fluorescence sensing， and lateral flow immunoassay sensing. It focused on reviewing the application research progress of μPADs in environmental monitoring， food inspection and medical diagnosis for antibiotic detection， and analyzed the challenges faced by μPADs and their future development directions. |
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