单分散纤维素寡糖调控钴酸镍纳米酶结构性能研究

吴珂; 于世博; 鲁辰淇; 赵恬; 袁博雅; 宋宁宁; 陈攀; 张金明; 梁敏敏; 李唯

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Regulation of the Structural and Catalytic Properties of NiCo₂O₄ Nanozymes Using Monodisperse Cellulose Oligomers

Received:September 28, 2025 Revised:November 19, 2025

DOI：10.11981/j.issn.1000-6842.2025.04.60

Key Words:nanozymes;NiCo₂O₄;cellulose;catalytic efficiency

Fund Project:北京市自然科学基金（L254007）；河北省自然科学基金（B2023105020）；中国科协青年人才托举工程（2024QNRC0372）；北京理工大学青年教师启动计划（XSQD-202108010）。

Author Name	Affiliation	Postcode
WU Ke^*	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
YU Shibo	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
LU Chenqi	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
ZHAO Tian	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
YUAN Boya	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
SONG Ningning	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
CHEN Pan	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
ZHANG Jinming	CAS Key Lab of Engineering Plastics， Institute of Chemistry， Chinese Academy of Sciences， Beijing， 100190	100190
LIANG Minmin^*	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081
LI Wei^*	School of Materials Science and Engineering， Beijing Institute of Technology， Beijing， 100081	100081

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Abstract:

In this study， monodisperse cellulose oligosaccharides (MCOs) were introduced as molecular scaffolds to successfully synthesize MCOs@NiCo₂O₄ composite nanozymes. Benefiting from the excellent surface modification ability and confinement effect of MCOs， the nucleation and oriented growth of NiCo₂O₄ nanozymes were effectively guided， resulting in well-defined morphology and controllable surface chemical environments. Structural characterizations revealed that the incorporation of MCOs significantly improved the dispersion and interfacial chemistry of NiCo₂O₄ nanozymes， facilitating the exposure of active sites. Catalytic performance tests demonstrated that MCOs@NiCo₂O₄ composite nanozymes exhibited higher specific enzyme activity and reaction rate in the 3，3’，5，5’-tetramethylbenzidine (TMB)/H₂O₂ system. Moreover， by enhancing the catalytic rate per enzyme unit while maintaining substrate-binding ability， the overall catalytic efficiency was effectively improved. These results indicated that MCOs modification not only optimized the structural and surface properties of NiCo₂O₄ nanozymes but also enhanced its peroxidase-like activity， providing a novel design strategy and synthesis route for constructing structurally controllable and performance-tunable high-efficiency composite nanozymes.

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