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Self-assembly of Natural Polymer-embedded Single Cells for Biomedical Applications
Received:September 26, 2023  Revised:December 04, 2023
DOI:10.11981/j.issn.1000-6842.2024.01.114
Key Words:natural polymer;single-cell surface;layer-by-layer self-assembly;construction of shell layer
Fund Project:国家自然科学基金(52003146,52103008);陕西省重点研发计划国际科技合作项目(2023-GHZD-14);陕西省科协青年人才托举计划(20210407);陕西省自然科学基础研究(2021JQ-541)。
Author NameAffiliationPostcode
HE Bin College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
FANG Yifan College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
CHENG Lin College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
ZHENG Xulei College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
WANG Keyao College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
ZHU Xing College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
SONG Shunxi* College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi Province, 710021
National Demonstration Center for Experimental Light Chemistry Engineering Education, Xi'an, Shaanxi Province, 710021 
710021
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Abstract:
      Layer-by-Layer self-assembly method for preparation of natural polymer functionalized materials has emerged as a promising research direction in recent years, owing to its straight forward operation, gentle reaction conditions, and flexibility in adapting the shell layer structure. This review outlined the use of natural polymers like starch, chitosan, sodium alginate, gelatine, and cellulose to create single-cell shell layers through electrostatic Layer-by-Layer self-assembly. It also discussed the impact of the self-assembly process on the properties such as cell activity and pH tolerance, offering insight into the potential application of immobilized cells in biomedicine.
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